Technical Can you put a Chevy 350 trans behind an S-10 v6

Lead line sats it all.

 

Yes.
https://www.google.com/amp/s/www.sp...llhousing-adapters~131598-199-25-20-458-30217

 

Take a look at th350 long tail shafts. Used to common to swap 700r4's for th350 longs, to avoid having to make a new driveshaft. 4l60 is a progression of 700r4, but the lengths may have changed.
If it's not original vehicle application. Disregard.

 

depends which S10 V6 you have. If it's the later 4.3, then yes. If it's the older 2.8, then no.