Multi carb intake question

I've seen three and six carb intakes with one and two functioning center carbs.If the intake was designed to run three or six cabs will the mill run efficiently with blocked off outer carbs? Seems like there would be a rich/lean and temp difference a**** the cylinders closest and farthest from the functioning carb(s). O.K.to run on center(s) only? Thanks for your answer.
-Strat.

 

Single two barrel intakes work. Seems to me like it's the same thing.

 

Engine vac*** will 'draw' the fuel to where it needs to be.......

 

Most tripower setups run on only the center carb 98 per cent of the time anyway.