For those who have any idea that the fill rate of all cylinders is always equal, take a look at the calibrations Chrysler engineers did on the carburetors used on the dual quad hemi. Dual Carter AFB's with 4 different step-up rods, and 8 different jets. Chrysler probably only added this complexity to jack up the price of the car. There was probably no performance gain. This would have been quite a tuning exercise prior to the invention of O2 sensors and computers. Lots of fuel economy AND horsepower lost simply by bolting on a carburetor or carburetors with no prior planning and no subsequent testing. Jon.
I have run several 3x2 and 2x4 setups over the years with little to no problems, even a 2x4 setup where both carbs had idle circuits. I would try to run all the carbs on your manifold, its not that hard to make work. My current project has 6x2 setup and I plan to make it work and I am getting close to firing it! Below is a pic of it mocked up, its in the truck now. Oh, and this a 283 not a big inch motor.
Blocking off multi carbs is a good way to go for cars that aren't driven hard or regularly. You don't have all that stale gas gumming up the secondaries. I blocked off the back carb of the dual quads on my 67 GT500 and the front and rear carbs of the tripower on my 67 427 Corvette. Folks at shows are always amazed at how much better my cars start and run than theirs. As mentioned several times in this thread, you have to make sure that the intake is designed to feed all the cylinders from the single carb. Many of the old flathead dual carb setups aren't. You can't block off carbs or run progressive linkage, and must run both carbs all the time.