Something like I did once, but for a banger. Mine worked and I don't know why more people don't do the same.
aren't the throttle bodys just the air metering system for the ECM? Where are you planning on putting the injectors?
If you use Motorcycle throttle bodies they have bosses cast into them for the injectors. In my case I just drilled these holes for 1/2-20 and used Hilborn nozzles. On the 250 Chevy deal the OP proposed you would have bosses at each port face for a nozzle. Which again is what I did except I used Hilborn nozzles.