The fenders have an inner and outer skin with a cavity on the inside. From the vendor the two fender panels were spot welded and EDP coated. How concerned should I be about dust within this cavity before applying epoxy primer. Some areas may be difficult to reach. Is just using a air gun to blow out the dust good enough?
If you blow it out it should be good to prime. At some point after the paint is done, I would spray a rust inhibitor into the gap. If there is bare metal in there your fenders will eventually rust from the inside out. The reason to wait is to ensure you don’t contaminate the surface area that is getting painted.
Use any paraffin base cavity wax type product after all painting is finished. It is the same stuff dealerships use to rustproof new cars. If the car is regularly exposed to the elements you can reseal the rust prone areas after 5 to 10 years for added insurance.